Intrahepatic arterial infusion with 5-fluorouracil
نویسندگان
چکیده
منابع مشابه
Intra-arterial hepatic chemotherapy combined with continuous infusion of 5-fluorouracil in patients with metastatic cholangiocarcinoma.
Cholangiocarcinoma refers to primary cancer of intrahepatic bile ducts. Resection is the most effective treatment, with a median survival of 36 months and a 5-year survival rate of 50%; however, unresectable tumors have a very poor prognosis with a median survival of 11 months and a 3-year survival rate of 21% [1, 2]. No good chemotherapy regimen is currently available, but 5-fluorouracil (5-FU...
متن کاملRegional arterial infusion with 5-fluorouracil attenuates severe acute pancreatitis in a rat model
Administration of 5-fluorouracil (5-FU) has been demonstrated to be beneficial in treating severe acute pancreatitis (SAP). However, drugs administered by intravenous injection (IVI) have difficulty to reach the pancreatic tissue. In this study, we aimed to assess the effects of 5-FU administered with regional arterial infusion (RAI) on severe acute pancreatitis (SAP) in rats. Rats were randoml...
متن کاملTreatment of palmoplantar keratoderma with continuous infusion 5-fluorouracil.
A 49-year-old man electively chose to undergo a trial of intravenous chemotherapy with 5-fluorouracil (5-FU) for his inherited punctate palmoplantar keratoderma (PPK). His father also had this skin disorder, which coincidentally cleared after 2 courses of chemotherapy consisting of 5-FU and cisplatin to treat his lung cancer, prompting the patient to undergo this trial of therapy. After the pat...
متن کاملPharmacokinetics of 5-fluorouracil following hepatic intra-arterial infusion in a VX2 hepatic metastasis model.
BACKGROUND Hepatic intra-arterial infusion chemotherapy of 5-fluorouracil (5-FU) or fluorodeoxyuridine (FUDR) has been a treatment option for liver metastasis from colorectal cancer. However, an optimal administration schedule of 5-FU is still controversial. This study was conducted to evaluate a suitable schedule from the viewpoint of 5-FU metabolites and related enzymes. METHODS 5-FU was in...
متن کاملBolus 5-fluorouracil as an alternative in patients with cardiotoxicity associated with infusion 5-fluorouracil and capecitabine: a case series.
BACKGROUND 5-Fluorouracil (5-FU) is the backbone of chemotherapy regimens approved for treatment of colorectal cancer. The incidence of cardiotoxicity associated with 5-FU ranges from 1.5% to 18%; 48% as anginal symptoms and 2% as cardiogenic shock. Cardiotoxicity is unpredictable and no alternative chemotherapeutics have been defined so far. PATIENTS AND METHODS We present a case series of s...
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ژورنال
عنوان ژورنال: Cancer
سال: 1971
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(1971)28:5<1147::aid-cncr2820280510>3.0.co;2-l